Description

Desformylgramicidin is a derivative of the gramicidin family of linear peptide antibiotics, characterized by the absence of a formyl group on the N-terminal valine residue. This structural modification can influence its ionophoric activity and interaction with biological membranes, making it a valuable compound for research into antimicrobial mechanisms and membrane biophysics. It serves as a critical reference standard and intermediate for pharmaceutical research, particularly in the study of antibiotic resistance and novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Used as a key intermediate and reference standard in the synthesis and study of novel gramicidin-derived antibiotics.
• Biochemical Studies: Employed in research on ion channel formation, membrane permeability, and the mechanisms of antimicrobial action.
• Microbiology Research: Serves as a tool compound for investigating bacterial cell wall synthesis and developing assays for antibiotic susceptibility testing.
• Analytical Chemistry: Utilized as a high-purity standard for method development and quality control in HPLC and mass spectrometry analyses within pharmaceutical laboratories.

Basic Information

Item	Detail
Product Name	Desformylgramicidin
CAS No.	63808-16-2
Molecular Formula	C99H140N20O17
Molecular Weight	1882.3 g/mol
Synonyms	Desformyl Gramicidin; N-Desformylgramicidin; Gramicidin F; Gramicidin, desformyl-; Gramicidin A, desformyl-; Val-Gramicidin A; Linear Gramicidin Derivative
EINECS	Contact for details

Quality Control

Our Desformylgramicidin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and meets stringent in-house specifications for research use. A Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.