Description

L-A-Hydroxyglutaric Acid Disodium is a high-purity, water-soluble salt form of the biologically significant L-2-hydroxyglutaric acid. This compound matters as a critical biochemical standard and intermediate for research and development in life sciences. It is needed by manufacturers and researchers in the pharmaceutical, diagnostic, and biotechnology sectors for applications ranging from enzyme studies to the synthesis of advanced therapeutic agents.

Application

• Biochemical Research & Standard: Used as a reference standard in metabolic studies, particularly for research into L-2-hydroxyglutaric aciduria and related mitochondrial disorders.
• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates and active pharmaceutical ingredients (APIs).
• Enzymology Studies: Employed as a specific substrate or inhibitor in assays for dehydrogenases and other enzymes involved in glutaric acid metabolism.
• Diagnostic Reagent Manufacturing: A component in the formulation of calibrators and controls for clinical diagnostic kits targeting inborn errors of metabolism.
• Cell Culture & Media Supplement: Used in specialized cell culture media for metabolic research applications.

Basic Information

Product Name	L-A-Hydroxyglutaric Acid Disodium
CAS No.	63512-50-5
Molecular Formula	C5H6Na2O6
Molecular Weight	208.08 g/mol
Synonyms	L-2-Hydroxyglutaric Acid Disodium Salt; Disodium L-2-Hydroxyglutarate; (2S)-2-Hydroxypentanedioic Acid Disodium Salt; L-2-HG Disodium; 2-Hydroxyglutaric Acid Disodium Salt (L-form); Disodium (2S)-2-Hydroxy-1,5-pentanedioate; L-α-Hydroxyglutaric Acid Disodium Salt
EINECS	Contact for details

Quality Control

Our L-A-Hydroxyglutaric Acid Disodium is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 2.0%
pH (5% solution)	7.0 - 9.0
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.