Description

1-Hydroxy-1H-Benzotriazole, Ammonium Salt is a high-purity, water-soluble ammonium salt derivative of a key benzotriazole-based coupling agent. This compound is valued for its enhanced stability and solubility profile compared to its parent acid, making it a critical reagent in modern synthetic chemistry. It is primarily sought by manufacturers and research institutions in the pharmaceutical, agrochemical, and specialty chemical sectors for peptide synthesis and other condensation reactions.

Application

• As an efficient peptide coupling additive in solid-phase and solution-phase peptide synthesis.
• As a catalyst or activator in amide bond formation and other condensation reactions in pharmaceutical intermediate manufacturing.
• As a reagent in the synthesis of complex organic molecules and active pharmaceutical ingredients (APIs).
• For research and development applications in medicinal chemistry and biochemistry laboratories.
• In the production of agrochemicals and other fine chemicals requiring high-yield coupling steps.
• As a stabilizing agent or intermediate in specialized polymer and material science applications.

Basic Information

Product Name	1-Hydroxy-1H-Benzotriazole, Ammonium Salt
CAS No.	63307-62-0
Molecular Formula	C6H6N4O • H3N
Molecular Weight	183.17 g/mol (for C6H6N4O)
Synonyms	HOBt Ammonium Salt; Ammonium 1-Hydroxybenzotriazole; 1-Hydroxybenzotriazole Ammonium Salt; HOBt•NH3; 1H-Benzotriazol-1-ol, ammonium salt; Coupling Reagent HOBt Ammonium Salt; Ammonium HOBt; Benzotriazol-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate activator related salt
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-1H-Benzotriazole, Ammonium Salt is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards expected in pharmaceutical and research-grade chemical supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.