Description

Benzyloxycarbonyl-Alanyl-Alanyl-Lysyl-4-Methoxy-2-Naphthylamide is a specialized synthetic peptide substrate designed for enzymatic research and biochemical analysis. This compound is of critical importance for studying protease activity, particularly in the context of enzyme kinetics and inhibitor screening. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers engaged in advanced biochemical and proteomic studies.

Application

• Protease/Enzyme Substrate: A key reagent for the fluorometric assay of specific proteolytic enzymes, including cathepsins and other lysosomal cysteine proteases.
• Biochemical Research: Used in fundamental research to investigate enzyme mechanisms, kinetics, and substrate specificity in controlled laboratory settings.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) campaigns to identify and characterize novel protease inhibitors as potential drug candidates.
• Diagnostic Reagent Manufacturing: Serves as a critical component in the formulation of diagnostic kits for measuring specific enzyme activities in clinical and research samples.
• Cell Biology Studies: Applied in assays to monitor protease activity within cellular pathways, aiding in the study of apoptosis, protein turnover, and signal transduction.

Basic Information

Product Name	Benzyloxycarbonyl-Alanyl-Alanyl-Lysyl-4-Methoxy-2-Naphthylamide
CAS No.	63244-88-2
Molecular Formula	C₃₄H₄₄N₆O₈
Molecular Weight	652.75 g/mol
Synonyms	Z-Ala-Ala-Lys-4-Methoxy-2-Naphthylamide; Z-Ala-Ala-Lys-MNA; Z-A-A-K-MNA; Cbz-Ala-Ala-Lys-MNA; Benzyloxycarbonyl-Ala-Ala-Lys-4-Methoxy-β-naphthylamide; Cathepsin B Substrate (Z-A-A-K-MNA); Fluorogenic Peptide Substrate Z-A-A-K-MNA; Nα-CBZ-L-alanyl-L-alanyl-Nε-CBZ-L-lysyl-4-methoxy-2-naphthylamide
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonyl-Alanyl-Alanyl-Lysyl-4-Methoxy-2-Naphthylamide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques, including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to degradation. For long-term stability, store desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.