Description

(6R,S)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride is a chemically synthesized, dihydrochloride salt form of a reduced pterin derivative, a critical cofactor in enzymatic processes. This compound is essential for research and development in biochemistry and pharmaceutical sciences, where precise cofactor activity is required. It is primarily utilized by researchers in academic institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focusing on neurotransmitter synthesis and metabolic pathway studies.

Application

• Biochemical Research: Used as a crucial cofactor in studies of aromatic amino acid hydroxylases, such as phenylalanine, tyrosine, and tryptophan hydroxylase.
• Pharmaceutical Development: Serves as a reference standard and active ingredient precursor in the development of therapies for metabolic disorders related to tetrahydrobiopterin (BH4) deficiency.
• Diagnostic Reagents: Incorporated into enzymatic assay kits for the clinical measurement of phenylalanine levels, aiding in the diagnosis and monitoring of phenylketonuria (PKU).
• Cell Culture & Neuroscience: Employed in in vitro studies to support nitric oxide synthase (NOS) activity and research into neurotransmitter synthesis pathways.
• Enzyme Activity Studies: Acts as a substrate or cofactor in kinetic and mechanistic studies of pterin-dependent enzymes.

Basic Information

Product Name	(6R,S)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride
CAS No.	62989-33-7
Molecular Formula	C9H17N5O3 • 2HCl
Molecular Weight	336.19 g/mol (free base: 255.27)
Synonyms	6R,S-Tetrahydro-L-biopterin dihydrochloride; (6R,S)-BH4 2HCl; 5,6,7,8-Tetrahydro-L-biopterin dihydrochloride (racemic); L-erythro-5,6,7,8-Tetrahydrobiopterin dihydrochloride; Sapropterin dihydrochloride (racemic form); (6R,S)-THB dihydrochloride; 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride
EINECS	Contact for details

Quality Control

Our (6R,S)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, suitable for research applications. Quality is verified by techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.