Description

Uric Acid (1,3-15N2) CAS NO 62948-75-8 is a stable isotope-labeled analog of uric acid, where two nitrogen atoms at the 1 and 3 positions are enriched with the 15N isotope. This compound is an essential tool for advanced analytical research, enabling precise quantification and metabolic pathway tracing through techniques like mass spectrometry and NMR. It is primarily required by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for use as an internal standard in quantitative bioanalysis, metabolic flux studies, and the development of clinical assays.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous uric acid in biological matrices (plasma, serum, urine) for clinical research and diagnostic test development.
• Metabolic Pathway Analysis: Used in 15N tracer studies to investigate purine metabolism, nitrogen recycling, and related disorders in both in vitro and in vivo systems.
• NMR Spectroscopy: Serves as a valuable reference standard in nuclear magnetic resonance studies due to its distinct isotopic signature, aiding in structural elucidation and dynamic studies.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies for drugs targeting conditions like gout, hyperuricemia, and kidney disease.
• Diagnostic Kit Manufacturing: Integrated into the calibration and validation of high-precision clinical diagnostic kits and reagents for uric acid measurement.
• Biomarker Research: Facilitates the discovery and validation of uric acid as a biomarker in various metabolic and cardiovascular disease studies.

Basic Information

Item	Detail
Product Name	Uric Acid (1,3-15N2)
CAS No.	62948-75-8
Molecular Formula	C5H415N2O3
Molecular Weight	170.10 g/mol (for 15N2 labeled form)
Synonyms	1,3-15N2-Uric Acid; [1,3-15N2]Uric Acid; Uric Acid-15N2 (1,3); 7,9-Dihydro-1H-purine-2,6,8(3H)-trione-1,3-15N2; 2,6,8-Trihydroxypurine-1,3-15N2; Isotopically Labeled Uric Acid; 15N Labeled Uric Acid Standard
EINECS	Contact for details

Quality Control

Our Uric Acid (1,3-15N2) is manufactured under strict quality protocols to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % 15N), chemical purity by HPLC, and identification by spectroscopic methods. We adhere to relevant industry standards for stable isotope-labeled compounds, ensuring reliable performance and traceability in your research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 15N)	≥ 98%
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.