Description

Guanosine, 2'-o-Methyl-5'-o-Phosphonoadenylyl-(3'→5')- is a chemically modified dinucleotide, specifically a guanosine-adenosine dinucleotide with a 2'-O-methyl group on the guanosine and a 5'-phosphonate group on the adenosine. This compound is a critical building block and research tool in the development of oligonucleotide therapeutics, including antisense oligonucleotides and siRNA, due to its enhanced nuclease resistance and binding affinity. It is essential for pharmaceutical R&D, biotechnology companies, and academic institutions focused on advanced nucleic acid chemistry and drug discovery.

Application

• Oligonucleotide Synthesis: A key phosphoramidite or solid-support intermediate for the automated synthesis of therapeutic oligonucleotides.
• Antisense Drug Development: Used to create modified oligonucleotides that target and modulate specific RNA sequences to treat genetic disorders, cancers, and viral infections.
• siRNA and miRNA Research: Incorporated into small interfering RNA (siRNA) or microRNA (miRNA) strands to improve stability and potency in gene silencing applications.
• Diagnostic Probe Design: Serves as a component in high-specificity molecular probes and primers for advanced diagnostic assays and PCR applications.
• Structural Biology Studies: Utilized in NMR and X-ray crystallography to study RNA structure, function, and protein-RNA interactions.
• Apitamer Development: Employed in the synthesis of modified nucleic acid libraries for the selection of high-affinity aptamers against therapeutic targets.

Basic Information

Product Name	Guanosine, 2'-o-Methyl-5'-o-Phosphonoadenylyl-(3'→5')-
CAS No.	62828-60-8
Molecular Formula	C21H27N10O13P2
Molecular Weight	713.45 g/mol
Synonyms	2'-O-Methylguanylyl-(3'→5')-adenosine 5'-phosphonate; G(2'-OMe)-A(P); 2'-O-Methyl-G-A(P) dinucleotide; 2'-O-Methyl-GpA(P); Adenosine 5'-phosphonate, 2'-O-methylguanylyl-(3'→5')-; 2'-O-Me-G-A(P); Dinucleotide phosphonate analog; Modified RNA dinucleotide
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical follows strict quality protocols aligned with GMP principles for pharmaceutical intermediates. Every batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to ensure structural integrity and purity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Purity (NMR)	≥ 90%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.