Description

Peg10-Tos CAS NO 62573-11-9 is a polyethylene glycol (PEG) derivative functionalized with a tosylate (p-toluenesulfonate) group, specifically featuring a 10-unit ethylene oxide chain. This bifunctional molecule is a versatile chemical intermediate, prized for its ability to act as a reactive linker, enabling the PEGylation of other molecules or surfaces. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and specialty chemical sectors who require reliable, high-purity building blocks for conjugation, solubilization, and controlled-release applications.

Application

• Pharmaceutical Intermediates: Key starting material for the synthesis of PEGylated active pharmaceutical ingredients (APIs) and prodrugs to enhance solubility and bioavailability.
• Bioconjugation: Used as a linker to attach polyethylene glycol chains to peptides, proteins, or antibodies, a process critical for creating long-acting therapeutics (e.g., PEGylated interferons).
• Polymer Chemistry: Serves as a macro-initiator or functional monomer in the synthesis of block copolymers and functionalized polymeric materials.
• Surface Modification: Employed to introduce hydrophilic PEG coatings onto nanoparticles, medical devices, or diagnostic surfaces to reduce non-specific binding and improve biocompatibility.
• Cross-linking Agent: Utilized in the preparation of hydrogels and polymer networks where controlled cross-linking density is required.
• Specialty Surfactants & Lubricants: Acts as a precursor for synthesizing non-ionic surfactants and functional lubricants with specific reactive end-groups.

Basic Information

Product Name	Peg10-Tos
CAS No.	62573-11-9
Molecular Formula	C23H40O13S
Molecular Weight	556.62 g/mol
Synonyms	Poly(ethylene glycol) 10 p-toluenesulfonate; PEG10 Tosylate; α-Methyl-ω-(p-toluenesulfonyl)polyethylene glycol (n=10); 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(4-Methylbenzenesulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; mPEG10-OTs; Tos-PEG10-OH; PEG 500 Tosylate
EINECS	Contact for details

Quality Control

Our Peg10-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets precise specifications for critical applications. A comprehensive Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.