Description

Nsc 26480 (5,6-Dihydro-5-Azacytidine) is a chemically modified nucleoside analog of cytidine, designed for enhanced stability and specific biological activity. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a DNA methyltransferase inhibitor. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications in oncology research, epigenetics studies, and as a key intermediate in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced investigational drugs and epigenetic modulators.
• Oncology Research: Used in biochemical and cellular assays to study mechanisms of action related to DNA methylation and cancer cell proliferation.
• Epigenetics Studies: A valuable tool compound for investigating gene expression regulation and chromatin remodeling pathways.
• Biochemical Reference Standard: Employed as a high-purity standard for analytical method development and validation in QC laboratories.
• Academic & Contract Research: Utilized in university and CRO settings for fundamental research into nucleoside chemistry and its biological implications.

Basic Information

Product Name	Nsc 26480 (5,6-Dihydro-5-Azacytidine)
CAS No.	62402-31-7
Molecular Formula	C8H13N3O5
Molecular Weight	231.21 g/mol
Synonyms	5,6-Dihydro-5-azacytidine; NSC-26480; 5-Aza-5,6-dihydrocytidine; 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one; Dihydro-5-azacytidine; 5,6-Dihydro-5-aza-cytidine
EINECS	Contact for details

Quality Control

Our Nsc 26480 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.