Description

Dextran-2-Hydroxy-3-Mercaptopropyl Ether is a chemically modified polysaccharide derivative, where dextran is functionalized with a hydroxy-mercaptopropyl side chain. This modification introduces a reactive thiol (-SH) group, making it a valuable intermediate for conjugation, cross-linking, and surface modification in advanced biomaterial synthesis. It is particularly sought after by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing drug delivery systems, hydrogels, and biocompatible coatings. The compound's unique structure provides a versatile platform for creating tailored materials with controlled properties.

Application

• Bioconjugation and Protein Modification: Acts as a linker or carrier molecule for attaching therapeutic proteins, peptides, or drugs via thiol-reactive chemistry.
• Hydrogel Formation: Serves as a cross-linking agent or building block for creating injectable or implantable hydrogels used in tissue engineering and regenerative medicine.
• Surface Functionalization: Used to modify the surface of nanoparticles, medical devices, or diagnostic sensors to enhance biocompatibility and introduce specific functional groups.
• Chromatography Media: Can be employed as a ligand or matrix component in affinity chromatography for protein purification.
• Controlled Release Systems: Incorporated into matrices for the sustained or targeted release of active pharmaceutical ingredients (APIs).
• Research & Development: A key reagent in academic and industrial R&D for exploring novel biomaterials and drug delivery mechanisms.

Basic Information

Product Name	Dextran-2-Hydroxy-3-Mercaptopropyl Ether
CAS No.	62340-64-1
Molecular Formula	(C6H10O5)n with C3H7O2S side chain
Molecular Weight	Varies (dependent on dextran backbone molecular weight and degree of substitution)
Synonyms	2-Hydroxy-3-mercaptopropyl dextran ether; Dextran, 2-hydroxy-3-mercaptopropyl ether; Thiolated dextran; Dextran-SH; Dextran mercaptopropyl ether; Dextran modified with 3-mercapto-1,2-propanediol; Dextran-(2-hydroxy-3-mercaptopropyl) ether; Polydextran thioether
EINECS	Contact for details

Quality Control

Our Dextran-2-Hydroxy-3-Mercaptopropyl Ether is produced under a rigorous quality management system. Each batch is characterized to ensure consistency in molecular weight distribution, degree of substitution (DS) of the thiol group, and purity. Standard quality control includes testing for residual solvents and heavy metals. A comprehensive Certificate of Analysis (COA) detailing assay, identification, and specific parameters is provided with every shipment. We support development projects and can work with clients to meet specific research-grade or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its easily oxidized nature. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, desiccants are recommended to minimize moisture uptake. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (Thiol Content)	≥ 0.5 mmol/g (or as per grade)
Degree of Substitution (DS)	0.05 - 0.3 (typical range)
Molecular Weight (Dextran Backbone)	10 kDa, 40 kDa, 70 kDa, or custom
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 5.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.