Description

Adenosine 2'-Phosphate 5-Phosphosulfate, Lithium Salt is a high-purity, biologically active nucleotide derivative essential for enzymatic sulfation reactions. This compound serves as the universal sulfate donor for sulfotransferase enzymes, making it a critical reagent in biochemical research and pharmaceutical development. It is primarily utilized by researchers in life sciences, biotechnology, and pharmaceutical companies for studying and developing drug metabolism, hormone regulation, and detoxification pathways.

Application

• Biochemical Research: Essential co-substrate for in vitro assays of sulfotransferase (SULT) enzyme activity and kinetics.
• Drug Metabolism Studies: Used to investigate Phase II conjugation pathways, crucial for understanding drug bioavailability, toxicity, and clearance.
• Pharmaceutical Development: Employed in the synthesis and testing of sulfated drug metabolites and prodrugs.
• Enzymology: Serves as a high-energy sulfate donor for studying the mechanism of sulfuryl group transfer in various biological systems.
• Diagnostic Reagent Manufacturing: A key component in diagnostic kits designed to measure sulfotransferase activity in clinical and research settings.
• Proteoglycan & Glycosaminoglycan Synthesis: Used in research focused on the sulfation of carbohydrates, which is vital for proteoglycan function.

Basic Information

Product Name	Adenosine 2'-Phosphate 5-Phosphosulfate, Lithium Salt
CAS No.	62230-89-1
Molecular Formula	C10H14LiN5O13P2S
Molecular Weight	529.16 g/mol
Synonyms	PAPS, Lithium Salt; Adenosine 3'-phosphate 5'-phosphosulfate lithium salt; 3'-Phosphoadenosine-5'-phosphosulfate lithium salt; 3'-Phosphoadenylyl sulfate lithium salt; Adenosine 3',5'-bisphosphate, sulfate lithium salt; PAPS Li Salt; Sulfate donor PAPS; 3'-Phospho-5'-adenylyl sulfate lithium salt
EINECS	Contact for details

Quality Control

Our Adenosine 2'-Phosphate 5-Phosphosulfate, Lithium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to meet the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity (Enzymatic Assay)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.