Description

(6S)-4,5-Didehydro-5,6,7,8,11,12-Hexahydroretinol is a specific, high-purity stereoisomer of a hydrogenated retinol derivative, a key intermediate in the synthesis of specialized retinoids. This compound matters for its role in enabling precise chemical transformations and producing advanced vitamin A analogs with targeted biological activity. It is primarily needed by pharmaceutical R&D teams, fine chemical manufacturers, and academic research institutions focused on dermatology, oncology, and nutritional science.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel retinoid-based drugs for treating skin conditions and certain cancers.
• Biochemical Research: Used as a reference standard or precursor in studies of vitamin A metabolism and retinoid signaling pathways.
• Cosmeceutical Ingredient Synthesis: Serves as a key starting material for developing advanced anti-aging and skin-repair actives.
• Nutraceutical Development: Employed in the research and production of specialized, high-potency vitamin A formulations.
• Organic Synthesis: A valuable chiral synthon for constructing complex polyene structures in academic and industrial laboratories.

Basic Information

Product Name	(6S)-4,5-Didehydro-5,6,7,8,11,12-Hexahydroretinol
CAS No.	62123-23-3
Molecular Formula	C20H30O
Molecular Weight	286.45 g/mol
Synonyms	(6S)-4,5-Didehydro-5,6,7,8-tetrahydroretinol; (6S)-4,5-Didehydro-5,6,7,8,11,12-hexahydrovitamin A alcohol; all-trans-(6S)-4,5-Didehydro-5,6,7,8,11,12-hexahydroretinol; Vitamin A derivative, hydrogenated; (6S)-Perhydroretinol derivative; Retinol, 4,5-didehydro-5,6,7,8,11,12-hexahydro-, (6S)-
EINECS	Contact for details

Quality Control

Our (6S)-4,5-Didehydro-5,6,7,8,11,12-Hexahydroretinol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and stereochemical integrity. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles are available upon request. We support development and cGMP-grade production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. For long-term storage, keep the sealed container in a freezer at -20°C or below. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Yellow to pale orange viscous oil or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 97.0%
Optical Rotation	Contact for details
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.