Description

De-n-Sulfated Heparin Sodium Salt is a chemically modified derivative of heparin, characterized by the selective removal of sulfate groups from the polysaccharide chain. This modification is critical for researchers investigating the structure-activity relationships of glycosaminoglycans and their specific biological interactions. It serves as a valuable tool compound in biochemical and pharmacological research, particularly for studying anticoagulant mechanisms and developing novel therapeutic agents. Key industries that utilize this specialized material include pharmaceutical R&D, biotechnology, and academic research institutions.

Application

• Biochemical Research: Used as a key reference standard and substrate for studying the enzymatic activity of sulfatases and heparin-degrading enzymes.
• Structure-Activity Relationship (SAR) Studies: Essential for investigating the role of specific sulfate groups in heparin's binding affinity to proteins like antithrombin III and growth factors.
• Pharmaceutical Development: Serves as a precursor or intermediate in the research and development of novel, targeted anticoagulant and anti-inflammatory drugs with potentially reduced side effects.
• Cell Culture & Regenerative Medicine: Applied in studies exploring the effects of modified heparins on stem cell differentiation, angiogenesis, and tissue engineering.
• Diagnostic Reagent Development: Utilized in the design and calibration of diagnostic assays that measure heparin levels or related enzymatic activities.
• Glycobiology Research: A fundamental tool for understanding the biosynthesis, function, and degradation of complex heparan sulfate proteoglycans.

Basic Information

Product Name	De-n-Sulfated Heparin Sodium Salt
CAS No.	61932-66-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Desulfated Heparin Sodium Salt; N-Desulfated Heparin Sodium; Heparin, desulfated, sodium salt; Partially Desulfated Heparin; 2-O, 3-O-Desulfated Heparin; De-O-sulfated Heparin; Heparin Derivative (Desulfated); Glycosaminoglycan Derivative
EINECS	Contact for details

Quality Control

Our De-n-Sulfated Heparin Sodium Salt is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and functional activity assays, to ensure consistency and reliability for research applications. A Certificate of Analysis (COA) detailing specific parameters such as degree of desulfation, purity, and biological activity is provided with every shipment to guarantee traceability and meet the stringent requirements of the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. For long-term storage, consider storing under inert atmosphere or at lower temperatures (2-8°C).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Complies
Assay (HPLC)	≥ 95%
Degree of Desulfation	Contact for details
Protein Content	< 1.0%
Water Content (KF)	< 5.0%
pH (Solution)	5.0 - 7.5
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.