Description

Chromozym Th is a chromogenic peptide substrate specifically designed for the selective and sensitive determination of thrombin activity. This compound is a critical reagent in biochemical research and diagnostic applications, enabling precise measurement of enzymatic function. It is essential for researchers and manufacturers in the fields of hemostasis, clinical diagnostics, and pharmaceutical development who require reliable tools for enzyme kinetics and assay development.

Application

• Thrombin Activity Assays: Primary substrate for the quantitative measurement of thrombin concentration and activity in research and diagnostic kits.
• Coagulation Research: Used in studies of blood coagulation pathways, inhibitor screening, and the investigation of thrombotic disorders.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) for the discovery and evaluation of novel anticoagulant and procoagulant drugs.
• Clinical Diagnostics: A key component in automated and manual test systems for assessing hemostatic function and monitoring anticoagulant therapy.
• Enzyme Kinetics: Serves as a specific substrate for determining kinetic parameters (Km, Vmax) of thrombin and related serine proteases.
• Quality Control: Used in the quality assurance of therapeutic proteins and biologics related to the coagulation cascade.

Basic Information

Product Name	Chromozym Th
CAS No.	61876-61-7
Molecular Formula	C30H38N8O9S
Molecular Weight	686.74 g/mol
Synonyms	Tosyl-Gly-Pro-Arg-p-nitroanilide acetate salt; Tos-Gly-Pro-Arg-pNA; Chromozym TH; Bz-Phe-Val-Arg-pNA (common related substrate); Thrombin Substrate I; S-2238 (alternative chromogenic substrate); H-D-Phe-Pip-Arg-pNA; p-Nitroanilide thrombin substrate
EINECS	Contact for details

Quality Control

Our Chromozym Th is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and performance consistency suitable for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), water content, and functional activity is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Functional Activity	Conforms to reference (δA/min/mg)
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.