Description

N(6)-Monobutyryl-2'-Deoxycyclic Adenosine Monophosphate is a chemically modified nucleotide analog designed for enhanced stability and membrane permeability in biological research. This compound is a crucial tool for studying intracellular signaling pathways, particularly those mediated by cyclic AMP (cAMP), due to its resistance to hydrolysis by phosphodiesterases. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery, cell biology studies, and biochemical assay development.

Application

• Biochemical Research: Used as a cell-permeable, hydrolysis-resistant analog of cyclic AMP (cAMP) to activate protein kinase A (PKA) and study downstream signaling events.
• Pharmaceutical Development: Serves as a reference standard or an active pharmaceutical ingredient (API) intermediate in the development of cardiovascular and metabolic disorder therapeutics.
• Cell Biology Studies: Employed to investigate the role of cAMP in processes like gene expression, ion channel regulation, and cellular metabolism in various cell lines.
• Diagnostic Reagent Manufacturing: Acts as a key component in the formulation of ELISA kits and other diagnostic assays targeting cAMP-dependent pathways.
• Signal Transduction Analysis: A vital tool for high-throughput screening (HTS) campaigns to identify novel modulators of adenylate cyclase or phosphodiesterase activity.

Basic Information

Product Name	N(6)-Monobutyryl-2'-Deoxycyclic Adenosine Monophosphate
CAS No.	61866-09-9
Molecular Formula	C14H20N5O7P
Molecular Weight	401.32 g/mol
Synonyms	N6-Monobutyryl-2'-deoxy-cAMP; 2'-Deoxy-N6-butyryl-cAMP; N6-Butyryl-2'-deoxyadenosine 3',5'-cyclic monophosphate; db-2'-deoxy-cAMP; 2'-Deoxy-N6-butyryladenosine cyclic 3',5'-(hydrogen phosphate); Butyryl-2'-deoxy-cAMP; cAMP analog, cell-permeable; 2'-Deoxy-N(6)-butyryl-cyclic AMP
EINECS	Contact for details

Quality Control

Our N(6)-Monobutyryl-2'-Deoxycyclic Adenosine Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high-purity biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.