Description

n-Formyl-Nle-Leu-Phe is a synthetic tripeptide derivative, specifically a formylated chemotactic peptide analog, widely utilized in biochemical and pharmacological research. Its primary value lies in its role as a potent and selective agonist for the formyl peptide receptor (FPR), making it a critical tool for studying neutrophil activation, chemotaxis, and inflammatory signaling pathways. This high-purity compound is essential for researchers and manufacturers in the fields of immunology, inflammation research, and drug discovery, where precise receptor-ligand interactions are paramount.

Application

• Biochemical Research: As a standard agonist for studying formyl peptide receptor (FPR) signaling, calcium mobilization, and superoxide production in neutrophils.
• Inflammation & Immunology Studies: Used to model and investigate the molecular mechanisms of acute inflammatory responses and leukocyte migration.
• Drug Discovery Screening: Serves as a reference compound in high-throughput screening (HTS) assays to identify novel FPR antagonists or modulators for therapeutic development.
• Cell Biology: Employed to induce and analyze neutrophil degranulation, phagocytosis, and other effector functions in controlled experimental settings.
• Peptide Chemistry Reference: Acts as a building block or analytical standard in peptide synthesis and characterization workflows.

Basic Information

Product Name	n-Formyl-Nle-Leu-Phe
CAS No.	61864-82-2
Molecular Formula	C26H40N4O5
Molecular Weight	488.62 g/mol
Synonyms	Formyl-Norleucyl-Leucyl-Phenylalanine; fNle-Leu-Phe; For-Nle-Leu-Phe-OH; N-Formyl-L-norleucyl-L-leucyl-L-phenylalanine; Chemotactic Peptide fNLPNTL; Formyl-Met-Leu-Phe Analog; Formyl Peptide Receptor Agonist; N-Formyl-Norleu-Leu-Phe
EINECS	Contact for details

Quality Control

Our n-Formyl-Nle-Leu-Phe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.