Description

(6α,9β,11β,16α)-21-(Acetyloxy)-9,11-Epoxy-6-Fluoro-16-Methyl-Pregna-1,4-Diene-3,20-Dione is a high-purity synthetic steroid derivative, recognized for its potent glucocorticoid receptor activity. This compound is a critical advanced pharmaceutical intermediate (API intermediate) in the synthesis of modern topical and systemic corticosteroids. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities developing next-generation anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potent corticosteroid APIs like Difluprednate and related analogues.
• Anti-inflammatory Drug Research: Serves as a core scaffold in medicinal chemistry for developing new topical treatments for dermatitis, psoriasis, and ocular inflammation.
• Glucocorticoid Receptor Studies: Used as a reference standard or active compound in biochemical assays and pharmacological research to study receptor binding and activity.
• Process Chemistry & Scale-up: Employed in process development and optimization for the commercial manufacturing of steroid-based pharmaceuticals.
• Analytical Standard: Provides a high-purity reference material for quality control (QC) and analytical method development (e.g., HPLC, GC) in pharmaceutical analysis.

Basic Information

Product Name	(6α,9β,11β,16α)-21-(Acetyloxy)-9,11-Epoxy-6-Fluoro-16-Methyl-Pregna-1,4-Diene-3,20-Dione
CAS No.	61618-91-5
Molecular Formula	C₂₄H₂₉FO₆
Molecular Weight	432.49 g/mol
Synonyms	21-Acetoxy-9,11-epoxy-6-fluoro-16-methylpregna-1,4-diene-3,20-dione; Difluprednate Intermediate; 6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde 21-acetate (related); 9,11β-Epoxy-6α-fluoro-16α-methyl-21-acetoxypregna-1,4-diene-3,20-dione; 6α-Fluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate 9,11-epoxide
EINECS	Contact for details

Quality Control

Our (6α,9β,11β,16α)-21-(Acetyloxy)-9,11-Epoxy-6-Fluoro-16-Methyl-Pregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets exacting standards for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.