Description

Adenosine 2',3'-Riboepoxide 5'-Triphosphate is a chemically modified nucleotide analog featuring a reactive epoxide group on the ribose ring. This unique structure makes it a valuable biochemical tool and research reagent for studying enzyme mechanisms, nucleic acid interactions, and cellular signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in advanced molecular biology and medicinal chemistry.

Application

• Enzyme Mechanism Studies: Acts as a substrate analog or irreversible inhibitor for ATP-dependent enzymes, including kinases and polymerases, to probe active site architecture and catalytic pathways.
• Nucleic Acid Research: Used in the synthesis of modified oligonucleotides to investigate RNA structure, function, and stability, or to create cross-linked nucleic acid probes.
• Biochemical Assay Development: Serves as a key component in high-throughput screening (HTS) assays to identify potential inhibitors or modulators of nucleotide-binding proteins.
• Medicinal Chemistry & Drug Discovery: Provides a scaffold for the development of novel therapeutic agents targeting purinergic signaling pathways or specific enzymatic activities.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the three-dimensional structure of protein-nucleotide complexes.
• Cell Signaling Research: Investigates the role of ATP analogs in intracellular signaling cascades and energy metabolism under controlled experimental conditions.

Basic Information

Item	Details
Product Name	Adenosine 2',3'-Riboepoxide 5'-Triphosphate
CAS No.	61468-92-6
Molecular Formula	C10H14N5O13P3
Molecular Weight	521.15 g/mol
Synonyms	2',3'-Epoxy-ATP; 2',3'-Epoxyadenosine-5'-triphosphate; Adenosine 2',3'-epoxide 5'-triphosphate; 9-β-D-(2',3'-Epoxy)ribofuranosyladenine 5'-triphosphate; ATP 2',3'-epoxide; Reactive ATP analog; (2'R,3'S)-2',3'-Epoxy-2',3'-didehydro-2',3'-dideoxyadenosine 5'-triphosphate
EINECS	Contact for details

Quality Control

Our Adenosine 2',3'-Riboepoxide 5'-Triphosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and stability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.