Description

Cytidine Periodate Oxidized is a chemically modified nucleoside derivative where the ribose moiety of cytidine has been selectively oxidized by periodate. This modification is crucial for introducing reactive aldehyde groups, enabling its use as a versatile biochemical building block and cross-linking agent. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications such as oligonucleotide synthesis, bioconjugation, and the development of advanced therapeutic platforms.

Application

• Bioconjugation and Cross-linking: The reactive aldehyde groups facilitate the covalent attachment of cytidine derivatives to proteins, peptides, or other biomolecules for creating stable conjugates.
• Oligonucleotide Synthesis: Serves as a key modified intermediate in the solid-phase synthesis of oligonucleotides with specific functional handles for labeling or therapeutic purposes.
• Antiviral and Anticancer Prodrug Development: Used in research to synthesize nucleoside analogs that can be activated to target viral replication or cancer cell proliferation.
• Diagnostic Probe Manufacturing: Employed in the production of labeled probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic techniques.
• Biomaterial Functionalization: Applied to modify surfaces of polymers or nanoparticles with nucleoside motifs for targeted drug delivery systems.
• Enzyme Substrate Studies: Acts as a substrate or inhibitor analog in enzymatic studies to understand nucleoside-metabolizing enzymes.

Basic Information

Product Name	Cytidine Periodate Oxidized
CAS No.	61074-05-3
Molecular Formula	C9H11N3O5
Molecular Weight	241.20 g/mol
Synonyms	Periodate-Oxidized Cytidine; Cytidine 2',3'-Dialdehyde; 1-(2,3-Dideoxy-2,3-dialdehydro-β-D-*erythro*-pentofuranosyl)cytosine; 2',3'-O-Dialdehydrocytidine; Cytidine 2',3'-Diadelhyde; Oxidized Cytidine; Cytidine Dialdehyde
EINECS	Contact for details

Quality Control

Our Cytidine Periodate Oxidized is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and specific tests for residual solvents and periodate. We ensure compliance with relevant industry standards for research and pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Periodate	≤ 0.1%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.