Description

Teicoplanin A1 is a potent glycopeptide antibiotic and a major component of the teicoplanin complex, widely recognized for its efficacy against Gram-positive bacterial infections. Its primary commercial value lies in its critical role as a reference standard and active pharmaceutical ingredient (API) for the development and quality control of anti-infective drugs. This high-purity compound is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in antibiotic development, microbiological research, and chromatographic analysis.

Application

• Pharmaceutical Reference Standard: Serves as a primary chemical reference material (CRM) for the identification, assay, and impurity profiling of teicoplanin in pharmacopeial testing (USP, EP).
• Active Pharmaceutical Ingredient (API): Used in the formulation of injectable antibiotics for treating serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and other resistant Gram-positive bacteria.
• Microbiological Research: Employed in in vitro studies to determine minimum inhibitory concentrations (MICs) and investigate mechanisms of action and bacterial resistance.
• Analytical Chemistry: Utilized as a high-purity calibrant in HPLC, LC-MS, and other chromatographic methods for method development and validation.
• Biochemical Studies: Applied in research exploring the inhibition of bacterial cell wall synthesis and interactions with target peptides.

Basic Information

Product Name	Teicoplanin A1
CAS No.	61036-63-3
Molecular Formula	C88H95Cl2N9O33
Molecular Weight	1877.6 g/mol
Synonyms	Teicoplanin A1; Teicoplanin A1 component; Antibiotic MDL 507; Targocid (component A1); (3S,6R,9S,12R,15S,18R,21S,24S,27S,30S,33S)-30-[[2-[(Aminoacetyl)amino]acetyl]amino]-3-[(2R,3S,4R,5S,6S)-4,5-dihydroxy-6-methyl-3-(methylamino)oxan-2-yl]oxy-15-[(2R,3S,4S,5S,6R)-4,5-dihydroxy-3-(methylamino)-6-methyloxan-2-yl]oxy-6,9,12,18,21,24,27,33-octahydroxy-4,7,10,13,16,19,22,25,28-nonaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-31-yl] 2-(4-hydroxyphenyl)acetate; Teichomycin A1; MDL-507.
EINECS	Contact for details

Quality Control

Our Teicoplanin A1 is manufactured and tested under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and assay, IR and MS for identification, and stringent controls for related substances and residual solvents, ensuring compliance with relevant pharmacopeial standards. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming the product meets its defined specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 10.0 %
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.