Description

3'-Deoxynicotinamide Adenine Dinucleotide (CAS NO 60902-13-8) is a specialized nucleotide analog of NAD+, where the ribose moiety is modified by the absence of a hydroxyl group at the 3' position. This structural alteration makes it a valuable biochemical tool for studying enzyme mechanisms, particularly those involving NAD+-dependent dehydrogenases and sirtuins, where it can act as an inhibitor or a substrate analog. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers engaged in metabolic pathway analysis, aging research, and drug discovery.

Application

• Enzymology Research: Used as a substrate analog or competitive inhibitor to investigate the kinetics and mechanisms of NAD+-dependent enzymes, including dehydrogenases, reductases, and ADP-ribosyltransferases.
• Sirtuin Activity Studies: Serves as a critical reagent in assays measuring the deacetylase activity of sirtuin family proteins, which are implicated in aging, metabolism, and stress response.
• Diagnostic Kit Development: Incorporated into high-sensitivity assay kits for the clinical and research measurement of specific enzyme activities in biological samples.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel modulators (activators or inhibitors) of NAD+-utilizing protein targets.
• Metabolic Pathway Analysis: Aids in mapping and understanding cellular metabolic fluxes and redox states by interfering with specific NAD+-linked reactions.
• Biochemical Standard: Acts as a certified reference material for the calibration of analytical instruments and the validation of experimental methods in life science laboratories.

Basic Information

Product Name	3'-Deoxynicotinamide Adenine Dinucleotide
CAS No.	60902-13-8
Molecular Formula	C21H26N7O13P2
Molecular Weight	662.42 g/mol
Synonyms	3'-Deoxy-NAD+; 3'-dNAD; 3'-Deoxy Nicotinamide Adenine Dinucleotide; 3'-Deoxy NAD; Deamido-NAD (3'-deoxy); 3'-Deoxy-DPN; Adenosine 5'-(trihydrogen diphosphate), 5'-5'-ester with 3'-deoxy-1-(5-O-phosphono-β-D-ribofuranosyl)pyridinium, inner salt; 3'-Deoxy-β-nicotinamide adenine dinucleotide
EINECS	Contact for details

Quality Control

Our 3'-Deoxynicotinamide Adenine Dinucleotide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and identity confirmation via spectroscopic methods (UV, MS, NMR), to ensure it meets the high standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.