Description

Acetaminophen Mercapurate is a key metabolite and reference standard used in advanced pharmaceutical research and toxicology studies. This compound is critical for investigating the metabolic pathways and potential hepatotoxic effects associated with acetaminophen (paracetamol) overdose. It serves as an essential analytical standard for laboratories in the pharmaceutical, contract research organization (CRO), and diagnostic sectors requiring precise quantification and metabolic profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a high-purity certified reference material (CRM) for the calibration of analytical instruments and method validation in drug metabolism and pharmacokinetics (DMPK) studies.
• Toxicology and Safety Assessment: Crucial for research into acetaminophen-induced liver injury, used to study the formation of protein adducts and biomarkers of toxicity.
• Biomarker Analysis: Employed in the development and validation of clinical diagnostic assays to measure mercapturate conjugates in biological samples (e.g., urine, plasma) for patient monitoring.
• Metabolic Pathway Investigation: Used in vitro and in vivo studies to elucidate the glutathione conjugation pathway of acetaminophen, a key detoxification mechanism.
• Academic and Institutional Research: Serves as a vital reagent for universities and research institutes focusing on pharmacology, biochemistry, and molecular toxicology.
• Quality Control in Pharma Manufacturing: Applied in impurity profiling and stability testing of acetaminophen-based drug products to ensure safety and compliance.

Basic Information

Product Name	Acetaminophen Mercapurate
CAS No.	60603-13-6
Molecular Formula	C13H16N2O5S
Molecular Weight	312.34 g/mol
Synonyms	N-Acetyl-4-aminophenylmercapturic Acid; Acetaminophen Mercapturate; APAP Mercapturate; Paracetamol Mercapturate; N-Acetyl-S-(4-hydroxy-phenyl)-L-cysteine; 2-[(Acetyl-L-cystein-S-yl)-4-hydroxyaniline]; 2-[(4-Hydroxyphenyl)thio]-N-acetyl-L-alanine; Acetaminophen-Cysteine Adduct
EINECS	Contact for details

Quality Control

Our Acetaminophen Mercapurate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the stringent requirements for research and reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC, IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.