Description

1,2-Dimyristoyl-Sn-Glycerophosphomethanol, Sodium Salt is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylmethanol sodium salt. This compound is a critical intermediate and functional excipient valued for its role in modulating membrane properties and enhancing formulation stability. It is essential for researchers and manufacturers in advanced pharmaceutical development, particularly for lipid nanoparticle (LNP) systems, liposomal drug delivery, and as a key component in model membrane studies for biophysical research.

Application

• Lipid Nanoparticle (LNP) Formulation: A key phospholipid component for constructing stable, ionizable cationic lipid-based nanoparticles used in mRNA and siRNA delivery systems.
• Liposomal Drug Delivery: Used in the design and preparation of liposomes to improve encapsulation efficiency, control release profiles, and enhance targeting capabilities for therapeutic agents.
• Biomembrane & Model System Research: Serves as a critical building block for creating synthetic lipid bilayers and vesicles to study membrane biophysics, protein-lipid interactions, and cellular processes.
• Pharmaceutical Excipient: Acts as a stabilizer and solubilizing agent in complex injectable formulations and topical products.
• Bioconjugation & Surface Modification: The reactive headgroup facilitates covalent attachment of targeting ligands, peptides, or other functional molecules to lipid-based carriers.
• Cosmetic & Dermal Formulations: Employed in high-end cosmetic products as a lamellar structuring agent and enhancer of skin barrier function and active ingredient delivery.

Basic Information

Product Name	1,2-Dimyristoyl-Sn-Glycerophosphomethanol, Sodium Salt
CAS No.	60569-02-0
Molecular Formula	C33H66O8PNa
Molecular Weight	644.84 g/mol
Synonyms	DMPM (Na Salt); 1,2-Dimyristoylphosphatidylmethanol Sodium Salt; 1,2-Ditetradecanoyl-sn-glycero-3-phosphomethanol Sodium Salt; Phosphatidylmethanol, 1,2-dimyristoyl-, sodium salt; Sodium 1,2-dimyristoyl-sn-glycero-3-phosphomethanol; 14:0 PC-Me,Na+; DMPC-Me,Na+; (2,3-Dimyristoylpropyl) 2-(methoxy(hydroxy)phosphoryl)ethyl phosphate sodium salt
EINECS	Contact for details

Quality Control

Our 1,2-Dimyristoyl-Sn-Glycerophosphomethanol, Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.