Description

Succinimidyl 4-Formylbenzoate CAS NO 60444-78-2 is a high-purity, heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and an aldehyde group. This compound is essential for creating stable conjugates and bioconjugates, enabling the precise attachment of biomolecules, polymers, or surfaces under mild conditions. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, surface functionalization, and advanced material science.

Application

• Bioconjugation and ADC Development: A key reagent for site-specific conjugation of drugs, toxins, or fluorophores to antibodies, proteins, or peptides via amine-aldehyde coupling strategies.
• Surface Functionalization: Used to modify surfaces (e.g., chips, nanoparticles, beads) with aldehyde groups for subsequent immobilization of amine-containing biomolecules.
• Polymer and Dendrimer Modification: Enables the introduction of aldehyde handles onto polymers or dendrimers for further chemical elaboration or crosslinking.
• Hydrogel Formation: Acts as a crosslinker in the synthesis of hydrogels by reacting with amine-functionalized polymers.
• Diagnostic Assay Development: Employed in the preparation of enzyme-linked immunosorbent assay (ELISA) components and other diagnostic reagents.
• Protein Labeling and Pegylation: Facilitates the covalent attachment of polyethylene glycol (PEG) chains or other labels to proteins to enhance stability or add detection moieties.

Basic Information

Product Name	Succinimidyl 4-Formylbenzoate
CAS No.	60444-78-2
Molecular Formula	C12H9NO5
Molecular Weight	247.20 g/mol
Synonyms	4-Formylbenzoic Acid N-Hydroxysuccinimide Ester; 4-(2,5-Dioxopyrrolidin-1-yl)oxy)-4-oxobutyl Benzoate; 4-Formylbenzoyloxy Succinimide; NHS-4-Formylbenzoate; 4-Carboxybenzaldehyde N-Succinimidyl Ester; SFB; p-Formylbenzoic Acid Succinimidyl Ester; 4-(N-Succinimidyloxycarbonyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our Succinimidyl 4-Formylbenzoate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.