Description

(3α,5β,7α)-7-Hydroxy-3-(Sulfooxy)-Cholan-24-Oic Acid Disodium Salt is a high-purity, sulfated bile acid derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its primary commercial value lies in its role as a critical building block for producing therapeutic agents targeting liver and metabolic functions. This compound is essential for research institutions and pharmaceutical manufacturers engaged in developing and scaling up novel drug candidates, particularly in the hepatology and gastroenterology sectors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of therapeutic bile acids and their conjugates for liver disease treatments.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies related to bile acid metabolism and transport.
• Drug Discovery: Serves as a key starting material for medicinal chemistry programs aimed at developing novel FXR (Farnesoid X Receptor) agonists.
• Metabolic Pathway Analysis: Employed in in vitro and in vivo studies to investigate sulfation pathways and detoxification mechanisms.
• Diagnostic Reagent Development: Utilized in the formulation of calibrators and controls for clinical assays measuring bile acid profiles.

Basic Information

Product Name	(3α,5β,7α)-7-Hydroxy-3-(Sulfooxy)-Cholan-24-Oic Acid Disodium Salt
CAS No.	60237-34-5
Molecular Formula	C24H37Na2O8S
Molecular Weight	530.58 g/mol
Synonyms	7α-Hydroxy-3-sulfotaurocholic Acid Disodium Salt; Tauro-7α-hydroxy-3-sulfolithocholic Acid Disodium Salt; 3-Sulfo-7α-hydroxycholic Acid Taurine Conjugate Disodium Salt; 7α-Hydroxy-3-sulfolithocholyltaurine Disodium Salt; Disodium 7α-hydroxy-3-sulfolithocholyltaurate; 3α-Sulfo-7α-hydroxy-5β-cholan-24-oyltaurine Disodium Salt; Tauroursodeoxycholic Acid 3-Sulfate Disodium Salt
EINECS	Contact for details

Quality Control

Our (3α,5β,7α)-7-Hydroxy-3-(Sulfooxy)-Cholan-24-Oic Acid Disodium Salt is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) documenting purity, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.