Description

Ethynylestradiol 3--D-Glucuronide is a key conjugated metabolite of the synthetic estrogen ethinylestradiol. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and hormone-related biological pathways. It is primarily utilized by analytical laboratories, pharmaceutical companies, and academic research institutions engaged in bioanalytical method development, reference standard preparation, and metabolic profiling.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of ethinylestradiol metabolites in biological matrices during drug development and clinical studies.
• Bioanalytical Research: Used in the development and validation of LC-MS/MS, HPLC, and other analytical methods for precise detection and measurement in plasma, urine, and tissue samples.
• Metabolite Identification & Profiling: Essential for studying the metabolic fate, clearance pathways, and bioavailability of ethinylestradiol in preclinical and clinical research.
• Toxicology & Safety Assessment: Employed in investigations of estrogenic activity, endocrine disruption studies, and the long-term safety profile of hormonal compounds.
• Doping Control Analysis: Acts as a critical marker in sports anti-doping programs to detect the misuse of anabolic steroids and related substances.
• Enzyme Activity Studies: Used as a substrate to study the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in Phase II drug metabolism.

Basic Information

Product Name	Ethynylestradiol 3--D-Glucuronide
CAS No.	60134-76-1
Molecular Formula	C26H34O8
Molecular Weight	474.55 g/mol
Synonyms	Ethinyl Estradiol 3-Glucuronide; 17α-Ethynylestradiol 3-β-D-Glucuronide; EE2 3-Glucuronide; 19-Nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol 3-glucuronide; Ethynylestradiol Glucuronide; NSC 113927; Ethinylestradiol 3-Glucuronide
EINECS	Contact for details

Quality Control

Our Ethynylestradiol 3--D-Glucuronide is produced and handled under strict quality management protocols to ensure the highest standards of purity and consistency, suitable for sensitive analytical applications. Each batch is thoroughly characterized and tested using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.