Description

Petasitenine is a pyrrolizidine alkaloid of significant interest in pharmaceutical and biochemical research. This compound matters for its role as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of therapeutic agents. It is primarily needed by research institutions, pharmaceutical manufacturers, and analytical laboratories focused on natural product chemistry, toxicology studies, and drug discovery.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of pyrrolizidine alkaloids in drug substances and herbal products via HPLC, LC-MS, or GC-MS.
• Biochemical Research: Serves as a key intermediate or substrate in studies investigating the biosynthesis, metabolism, and hepatotoxic mechanisms of pyrrolizidine alkaloids.
• Natural Product Isolation & Synthesis: Acts as a target molecule for extraction, purification, and synthetic pathway development in academic and industrial laboratories.
• Toxicology & Safety Assessment: Employed as a calibrated standard in assays to screen for and quantify pyrrolizidine alkaloid contamination in food, feed, and botanical supplements.
• API Intermediate: Utilized in the controlled synthesis of more complex chemical entities for pharmacological evaluation.

Basic Information

Product Name	Petasitenine
CAS No.	60102-37-6
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	Petasitenine; (1R,7aR)-1-[(2Z)-2-Methylbut-2-enoyl]oxy-6,7,8,9-tetrahydro-5H-pyrrolizine-7a(1H)-carboxylic acid methyl ester; 7aβ-Hydroxy-1α-[(2-methyl-2-butenoyl)oxy]-8β-pyrrolizidinecarboxylic acid methyl ester; Senkirkine (Note: Senkirkine is a closely related isomer, often referenced together); Petasites alkaloid; PA standard
EINECS	Contact for details

Quality Control

Our Petasitenine is produced and handled under strict quality management protocols. Each batch undergoes rigorous identity confirmation, purity analysis, and impurity profiling to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identification tests, and related substance data is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.