Description

Tiazofurine is a synthetic purine nucleoside analogue with significant biochemical activity. This compound is valued for its role as a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the *de novo* biosynthesis of guanine nucleotides. It is primarily utilized by pharmaceutical research and development organizations, biotechnology companies, and academic institutions engaged in oncology research, antiviral studies, and the investigation of immunosuppressive agents.

Application

• Oncology Research: Investigated as a potential antineoplastic agent for its ability to inhibit cancer cell proliferation by disrupting nucleotide synthesis.
• Antiviral Research: Studied for its activity against various viruses, including herpesviruses, due to its mechanism of action on viral DNA synthesis.
• Immunology Studies: Used in research exploring immunosuppressive pathways, given its effect on lymphocyte proliferation.
• Biochemical Standard: Serves as a high-purity reference standard in analytical laboratories for method development and quality control.
• Enzyme Inhibition Studies: A critical tool for studying the structure and function of the IMPDH enzyme in biochemical assays.
• Preclinical Drug Development: Employed in the early-stage development and screening of new therapeutic candidates targeting nucleotide metabolism.

Basic Information

Product Name	Tiazofurine
CAS No.	60084-10-8
Molecular Formula	C9H12N4O5S
Molecular Weight	288.28 g/mol
Synonyms	2-β-D-Ribofuranosylthiazole-4-carboxamide; NSC 286193; Tiazofurin; 4-Carbamoyl-2-β-D-ribofuranosylthiazole; 2-β-D-Ribofuranosyl-4-thiazolecarboxamide; 4-Thiazolecarboxamide, 2-β-D-ribofuranosyl-; TR
EINECS	262-085-6

Quality Control

Our Tiazofurine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods, purity assay by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.