Description

γ-Lumicolchicine is a structural isomer of the potent alkaloid colchicine, derived from the autumn crocus (*Colchicum autumnale*). This compound is of significant interest in biochemical and pharmacological research due to its altered biological activity profile compared to colchicine. It serves as a critical reference standard and research tool for scientists investigating tubulin polymerization, cell cycle regulation, and anti-inflammatory pathways. Key industries that utilize this specialized chemical include pharmaceutical R&D, academic research institutions, and biotechnology companies focused on drug discovery and mechanism-of-action studies.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the study of gout treatments and anti-inflammatory agents.
• Biochemical Research: Serves as a crucial tool for investigating the inhibition of microtubule assembly and studying cell division (mitosis) in vitro.
• Academic Studies: Employed in university and institutional labs for pharmacological experiments targeting tubulin-binding sites and cytoskeleton dynamics.
• Analytical Chemistry: Functions as a high-purity certified reference material (CRM) for method development and calibration in HPLC, LC-MS, and other analytical techniques.
• Drug Discovery Programs: Utilized in high-throughput screening (HTS) and structure-activity relationship (SAR) studies to develop novel therapeutic agents.
• Toxicology Studies: Applied in research to understand the metabolic pathways and toxicological profiles of colchicine-related compounds.

Basic Information

Product Name	γ-Lumicolchicine
CAS No.	6901-14-0
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	γ-Lumicolchicine; NSC 51046; Colchicine, γ-lumi-; (S)-γ-Lumicolchicine; 3,4,5-Trimethoxy-19-methyl-9-oxo-1,2,3,4,4a,5,6,6a,7,9-decahydrobenzo[a]heptalen-7-yl acetate; Lumi-γ-colchicine; 7-Acetoxy-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
EINECS	Contact for details

Quality Control

Our γ-Lumicolchicine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected for high-purity research chemicals, supporting compliance in GLP (Good Laboratory Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C or as specified on the label) in a dry, well-ventilated area. Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.