Description

Dithioerythritol is a high-purity, versatile dithiol reducing agent widely used in biochemical and pharmaceutical research. Its primary value lies in its ability to reduce and cleave disulfide bonds in proteins and peptides under mild conditions, making it essential for maintaining protein structure and function. This compound is a critical reagent for researchers and manufacturers in the biotechnology, pharmaceutical, and diagnostic sectors who require reliable and effective thiol-based chemistry.

Application

• Protein Biochemistry: Reduction and denaturation of proteins for electrophoresis (e.g., SDS-PAGE) and structural analysis.
• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) where disulfide bond manipulation is required.
• Diagnostic Reagents: A key component in diagnostic kits and assays that rely on thiol-dependent enzymatic reactions or signal generation.
• Cell Culture & Research: Acts as an antioxidant in certain cell culture media to protect cells from oxidative stress.
• Polymer Chemistry: Serves as a chain transfer agent or cross-linking agent in the synthesis of specialized polymers.
• Bioconjugation: Facilitates the site-specific labeling of proteins and antibodies for imaging and therapeutic applications.

Basic Information

Product Name	Dithioerythritol
CAS No.	6892-68-8
Molecular Formula	C4H10O2S2
Molecular Weight	154.25 g/mol
Synonyms	DTE; (2R,3R)-1,4-Dimercaptobutane-2,3-diol; meso-1,4-Dimercapto-2,3-butanediol; Erythro-1,4-dimercapto-2,3-butanediol; Cleland's Reagent; Dithiothreitol isomer; 2,3-Dihydroxy-1,4-butanedithiol
EINECS	229-996-0

Quality Control

Our Dithioerythritol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and impurity profile analysis by HPLC, to ensure it meets high-purity standards suitable for research and industrial applications. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Melting Point	82 - 86 °C
Water Content (KF)	≤ 0.5 %
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.