Description

Curarine is a bisbenzylisoquinoline alkaloid, a member of the tubocurarine class of neuromuscular blocking agents. Its primary significance lies in its historical and research value as a classic non-depolarizing muscle relaxant, serving as a key reference compound in pharmacological and toxicological studies. This product is essential for researchers in pharmaceutical development, analytical laboratories, and academic institutions studying neuromuscular physiology, drug mechanisms, and the synthesis of related therapeutic agents.

Application

• Pharmacological Research: Used as a reference standard in studies of neuromuscular junction blockade and the mechanism of action of non-depolarizing muscle relaxants.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for qualitative and quantitative analysis in HPLC, LC-MS, and other chromatographic methods.
• Toxicology Studies: Employed in investigative toxicology to understand the effects and antidotes for curare-type poisoning.
• Biochemical Assays: Utilized in in vitro assays to study receptor binding and signal transduction at nicotinic acetylcholine receptors.
• Pharmaceutical Development: Acts as a chemical intermediate or a structural analog in the research and synthesis of novel neuromuscular agents.
• Academic & Educational Use: Provides a practical example of plant-derived alkaloids in university-level teaching and research in medicinal chemistry and pharmacology.

Basic Information

Product Name	Curarine
CAS No.	6880-94-0
Molecular Formula	C37H42N2O6
Molecular Weight	610.74 g/mol
Synonyms	d-Tubocurarine; Tubocurarine Chloride (common salt form); (+)-Tubocurarine; Curarin; Delacurarine; Tubarine; Intocostrin (brand name extract); 7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium
EINECS	Contact for details

Quality Control

Our Curarine is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.