Description

(+)-Himbacine CAS NO 6879-74-9 is a naturally occurring piperidine alkaloid isolated from the bark of *Galbulimima* species. This compound serves as a highly selective and potent antagonist for muscarinic acetylcholine receptors (mAChRs), particularly the M2 and M4 subtypes, making it a critical pharmacological tool. It is essential for researchers and developers in neuroscience, pharmacology, and drug discovery. Our supply ensures high purity and batch-to-batch consistency for reliable experimental and developmental outcomes.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and distribution of muscarinic acetylcholine receptor subtypes, particularly M2 and M4, in the central and peripheral nervous systems.
• Drug Discovery & Development: Used as a reference standard and lead compound in the development of novel therapeutics targeting cognitive disorders, cardiovascular conditions, and smooth muscle dysfunction.
• Biochemical Assays: Employed in in vitro binding assays and functional studies to characterize receptor-ligand interactions and screen for new receptor modulators.
• Academic & Pharmaceutical R&D: Supports fundamental research in academic institutions and preclinical development pipelines in pharmaceutical companies investigating cholinergic systems.
• Standard for Analytical Testing: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(+)-Himbacine
CAS No.	6879-74-9
Molecular Formula	C₂₂H₃₃NO₂
Molecular Weight	343.51 g/mol
Synonyms	(+)-Himbacine; Himbacine; (3β,12α)-3,12-Dimethoxyaspidospermidine; Galbulimima Alkaloid 13; NSC 168495; (3R,12R)-3,12-Dimethoxyaspidospermidine; CCG-142105; (3beta,12alpha)-3,12-Dimethoxyaspidospermidine
EINECS	Contact for details

Quality Control

Our (+)-Himbacine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards. We support cGMP practices for materials intended for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.