Description

Retronecine n-Oxide is a pyrrolizidine alkaloid derivative, a key chemical intermediate in advanced organic synthesis and pharmaceutical research. Its significance lies in its role as a versatile building block for the development of novel compounds and in toxicological studies related to pyrrolizidine alkaloids. This high-purity intermediate is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on alkaloid chemistry, medicinal chemistry, and analytical reference standards.

Application

• Pharmaceutical Research & Development: A critical intermediate in the synthesis of novel pharmaceutical candidates and for studying metabolic pathways.
• Medicinal Chemistry: Serves as a building block for creating analogs and derivatives with potential biological activity.
• Toxicology & Safety Assessment: Used as a reference standard in the analysis and toxicological profiling of pyrrolizidine alkaloids in food, herbal products, and the environment.
• Biochemical Research: Employed in studies investigating the biosynthesis, metabolism, and biological effects of alkaloids.
• Fine Chemical Synthesis: A specialized intermediate for the custom synthesis of complex natural product analogs and other high-value chemicals.
• Analytical Chemistry: Utilized as a certified reference material (CRM) for method development and calibration in HPLC, LC-MS, and other analytical techniques.

Basic Information

Product Name	Retronecine n-Oxide
CAS No.	6870-33-3
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	Retronecine N-Oxide; Retronecine 1-Oxide; (1R,7aR)-1-Hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl)methanol 1-oxide; Pyrrolizidine alkaloid metabolite; Heliotridine N-oxide isomer; 1-Hydroxymethyl-7-hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolizine 1-oxide
EINECS	Contact for details

Quality Control

Our Retronecine n-Oxide is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.