Description

(16R)-2α,5α-Epoxy-1,2-Dihydro-17-Hydroxyakuammilan-16-Carboxylic Acid Methyl Ester is a high-purity, structurally complex indole alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical intermediate or reference standard for the development of novel bioactive molecules, particularly within the fields of neuroscience and medicinal chemistry. It is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on alkaloid chemistry and drug discovery programs.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control, method validation, and analytical testing in drug development pipelines.
• Medicinal Chemistry Research: Serves as a key synthetic intermediate or precursor for the design and synthesis of new alkaloid-based therapeutic agents targeting neurological pathways.
• Biochemical Research: Employed in pharmacological studies to investigate receptor binding activity, enzyme inhibition, and other mechanism-of-action studies related to indole alkaloids.
• Academic & Institutional R&D: Utilized in university and institutional laboratories for fundamental research in natural product chemistry, total synthesis projects, and structural-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Acts as a building block for the custom synthesis of more complex, specialized molecules for clients in the life sciences sector.

Basic Information

Product Name	(16R)-2α,5α-Epoxy-1,2-Dihydro-17-Hydroxyakuammilan-16-Carboxylic Acid Methyl Ester
CAS No.	6808-68-0
Molecular Formula	C21H24N2O5
Molecular Weight	384.43 g/mol
Synonyms	Methyl (16R)-2α,5α-epoxy-1,2-dihydro-17-hydroxyakuammilan-16-carboxylate; 17-Hydroxyakuammilan-16-carboxylic acid methyl ester, 2α,5α-epoxy-1,2-dihydro-, (16R)-; Akuammilan-16-carboxylic acid, 2,5-epoxy-1,2-dihydro-17-hydroxy-, methyl ester, (16R)-; Related indole alkaloid intermediate.
EINECS	Contact for details

Quality Control

Every batch of (16R)-2α,5α-Epoxy-1,2-Dihydro-17-Hydroxyakuammilan-16-Carboxylic Acid Methyl Ester is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced analytical techniques such as HPLC, GC-MS, and NMR to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.