Description

Geranylgeranyl Pyrophosphate is a critical isoprenoid intermediate in the mevalonate pathway, essential for the biosynthesis of a wide range of biomolecules. Its primary commercial value lies in its role as a substrate for protein prenylation, a key post-translational modification that regulates cellular signaling and localization. This compound is indispensable for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly those focused on cancer research, metabolic studies, and the development of enzyme inhibitors.

Application

• Biochemical Research: Essential substrate for studying protein prenylation, geranylgeranylation enzymes (GGTases), and the regulation of small GTPases like Rho and Rac.
• Pharmaceutical Development: Used in high-throughput screening (HTS) assays to identify and characterize novel inhibitors targeting the mevalonate pathway for cancer and cardiovascular disease therapeutics.
• Enzyme Kinetics & Characterization: Serves as a key reagent for determining the kinetic parameters (Km, Vmax) of farnesyltransferase and geranylgeranyltransferase enzymes.
• Metabolic Pathway Analysis: A vital intermediate for in vitro reconstruction and study of the isoprenoid biosynthesis pathway, including the production of carotenoids, chlorophylls, and quinones.
• Cell Signaling Studies: Critical for investigating the role of prenylated proteins in cell proliferation, differentiation, and cytoskeletal organization.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for quality control and quantification in related biological samples.

Basic Information

Product Name	Geranylgeranyl Pyrophosphate
CAS No.	6699-20-3
Molecular Formula	C20H36O7P2
Molecular Weight	450.43 g/mol
Synonyms	GGPP; (all-E)-Geranylgeranyl diphosphate; Geranylgeranyl diphosphate; trans,trans,trans-Geranylgeranyl pyrophosphate; Farnesyl diphosphate, (3,7,11-trimethyl-2,6,10-dodecatrienyl) ester; All-trans-geranylgeranyl pyrophosphate; (all-trans)-Geranylgeranyl-PP
EINECS	229-782-7

Quality Control

Our Geranylgeranyl Pyrophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive biochemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material desiccated under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Assay (Enzymatic)	≥ 90%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.