Description

5'-Tosyl-2'-Deoxyadenosine is a key nucleoside derivative where the 5'-hydroxyl group is protected by a tosyl moiety. This modification is critical for controlling reactivity in synthetic pathways, making it an essential building block for the controlled synthesis of oligonucleotides and nucleotide analogs. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutics, diagnostic probes, and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of antiviral and anticancer nucleotide prodrugs.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase assembly of DNA strands and analogs.
• Biochemical Research: Used in studies of enzyme mechanisms, particularly those involving DNA polymerases and kinases.
• Prodrug Development: Employed in the design of masked nucleotide analogs to improve cellular uptake and metabolic stability.
• Labeled Compound Synthesis: Acts as a starting material for introducing radioactive or fluorescent tags into nucleic acid sequences.

Basic Information

Product Name	5'-Tosyl-2'-Deoxyadenosine
CAS No.	6698-29-9
Molecular Formula	C₁₇H₁₉N₅O₅S
Molecular Weight	405.43 g/mol
Synonyms	2'-Deoxyadenosine 5'-(4-methylbenzenesulfonate); 5'-O-Tosyl-2'-deoxyadenosine; 2'-Deoxy-5'-O-(p-toluenesulfonyl)adenosine; 5'-Tosyl-deoxyadenosine; dA-Tosyl; 9-[(2R,4S,5R)-4-Hydroxy-5-[[(4-methylphenyl)sulfonyl]oxymethyl]oxolan-2-yl]-9H-purin-6-amine; p-Toluenesulfonyl deoxyadenosine
EINECS	Contact for details

Quality Control

Our 5'-Tosyl-2'-Deoxyadenosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.