Description

11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Undecanoate CAS NO 6678-18-8 is a synthetic corticosteroid ester, specifically a prodrug of hydrocortisone. This compound is valued for its controlled-release properties and enhanced lipophilicity, which can improve bioavailability and therapeutic efficacy in specific formulations. It is primarily of interest to pharmaceutical R&D departments and manufacturers developing advanced topical, injectable, or transdermal drug delivery systems for anti-inflammatory and immunosuppressive applications.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the synthesis of more complex corticosteroid APIs (Active Pharmaceutical Ingredients).
• Prodrug Development: Utilized in research to create long-acting prodrug formulations of hydrocortisone, leveraging the undecanoate ester for modified release profiles.
• Topical Formulations: Investigated for use in creams, ointments, and gels aimed at treating dermatological conditions like eczema, psoriasis, and contact dermatitis.
• Injectable Depot Formulations: Potential candidate for developing sustained-release intramuscular or intra-articular injections for chronic inflammatory disorders.
• Veterinary Medicine: Applied in the development of anti-inflammatory and anti-pruritic treatments for animals.
• Biochemical Research: Serves as a reference standard or tool compound in steroid metabolism and glucocorticoid receptor interaction studies.

Basic Information

Product Name	11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Undecanoate
CAS No.	6678-18-8
Molecular Formula	C32H50O6
Molecular Weight	530.74 g/mol
Synonyms	Hydrocortisone 21-Undecanoate; Cortisol 21-Undecanoate; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-undecanoate; NSC 113927; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 21-undecanoate; Hydrocortisone Undecanoate; Undecanoic acid, (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-ester
EINECS	Contact for details

Quality Control

Our 11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Undecanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.