Description

Thymidine Glycol Monophosphate is a modified nucleoside monophosphate of significant interest in biochemical and pharmaceutical research. This compound serves as a critical building block and a model substrate for studying DNA damage, repair mechanisms, and nucleotide metabolism. It is primarily utilized by research institutions and biotechnology companies engaged in nucleic acid chemistry, enzymology, and the development of diagnostic or therapeutic agents.

Application

• Biochemical Research: Used as a standard or substrate in studies of oxidative DNA damage and repair pathways.
• Enzymology Studies: Acts as a specific substrate for enzymes like glycosylases and nucleotidyl transferases to investigate enzyme kinetics and specificity.
• Nucleotide Analog Synthesis: Serves as a key intermediate in the synthesis of modified nucleotides and potential antiviral or anticancer prodrugs.
• Diagnostic Development: Employed in the development of assays and kits for detecting DNA damage biomarkers.
• Reference Standard: Used as a high-purity analytical standard in HPLC or LC-MS for quantifying DNA lesions in biological samples.

Basic Information

Product Name	Thymidine Glycol Monophosphate
CAS No.	6168-31-6
Molecular Formula	C10H15N2O9P
Molecular Weight	338.21 g/mol
Synonyms	5,6-Dihydroxy-5,6-dihydrothymidine 5'-Monophosphate; 5',6-Dihydroxy-5',6'-dihydrothymidine 5'-Monophosphate; Thymine Glycol Monophosphate; 5-Hydroxy-6-hydroxy-5,6-dihydrothymidine 5'-Monophosphate; dTgMP; (5R,6S)-5,6-Dihydroxy-5,6-dihydrothymidine 5'-(Dihydrogen Phosphate)
EINECS	Contact for details

Quality Control

Our Thymidine Glycol Monophosphate is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. We adhere to ISO-guided standards for production and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the product should be stored in a cool, dry place, ideally at 2-8°C for long-term stability. For extended storage, consider desiccation. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.