Description

Protopine Hydrochloride is a high-purity alkaloid salt derived from natural sources, valued for its significant biological and pharmacological research applications. This compound is a critical reference standard and intermediate in the development of novel therapeutic agents and biochemical studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on neuroscience, cardiovascular research, and natural product chemistry.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in preclinical studies.
• Neuroscience & Neuropharmacology: Used in research investigating its effects on neurotransmitter systems and potential neurological applications.
• Cardiovascular Research: Employed in studies exploring its vasoactive properties and mechanisms of action on smooth muscle.
• Natural Product Chemistry & Analysis: Acts as a certified standard for the identification and quantification of protopine in plant extracts and herbal formulations.
• Biochemical Assay Development: Utilized as a reagent in high-throughput screening (HTS) and enzyme inhibition studies.
• Academic Research: A fundamental compound for university laboratories conducting studies in medicinal chemistry and pharmacology.

Basic Information

Product Name	Protopine Hydrochloride
CAS No.	6164-47-2
Molecular Formula	C20H20ClNO5
Molecular Weight	389.83 g/mol
Synonyms	Protopine HCl; Protopine Hydrochloride Salt; Fumaramine Hydrochloride; Macleyine Hydrochloride; 4,6,7,14-Tetrahydro-5-methylbis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one Hydrochloride; (13S)-5-Methyl-4,6,7,14-tetrahydro-13H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-b]isoquinolin-13-one Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Protopine Hydrochloride is manufactured under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.