Description

Trigonelline Hydrochloride is the hydrochloride salt of trigonelline, a natural alkaloid found in fenugreek seeds and coffee beans. This compound is a key reference standard and active ingredient valued for its role in metabolic and neurological research. It serves critical functions in the pharmaceutical, nutraceutical, and life science research sectors, particularly for studying diabetes, cognitive function, and plant biochemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quality control of herbal extracts and finished products.
• Nutraceutical & Dietary Supplement Formulation: Incorporated as an active ingredient in supplements targeting blood sugar management and metabolic health, leveraging its natural origin.
• Biochemical & Metabolic Research: A vital tool for in vitro and in vivo studies investigating insulin signaling pathways, glucose metabolism, and potential anti-diabetic mechanisms.
• Neuropharmacology Studies: Employed in research exploring its effects on cognitive function, neuroprotection, and acetylcholinesterase activity.
• Plant Physiology & Agriculture Research: Used to study alkaloid biosynthesis in plants and its role as a plant growth regulator.
• Cosmeceutical Ingredients: Investigated for potential applications in skin care formulations due to its antioxidant properties.

Basic Information

Product Name	Trigonelline Hydrochloride
CAS No.	6138-41-6
Molecular Formula	C7H8NO2·HCl
Molecular Weight	173.60 g/mol
Synonyms	Trigonelline HCl; Coffearine Hydrochloride; N-Methylnicotinic Acid Hydrochloride; 1-Methylpyridinium-3-carboxylate Hydrochloride; Gynesine Hydrochloride; Caffearine Hydrochloride; Nicotinic Acid N-Methylbetaine Hydrochloride
EINECS	Contact for details

Quality Control

Our Trigonelline Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and impurity profiling to ensure high chemical purity and consistency. Certificates of Analysis (COA) are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.