Description

6-Mercaptopurine Monohydrate is a purine analogue and antimetabolite pharmaceutical active ingredient, widely recognized for its critical role in therapeutic applications. Its primary value lies in its potent antiproliferative activity, which is essential for targeted medical treatments. This high-purity compound is primarily required by pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in oncology and immunology.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of prescription medications for specific cancer therapies.
• Oncological Treatments: Used in the chemotherapy regimens for acute lymphoblastic leukemia (ALL) and other neoplastic diseases.
• Immunosuppressive Therapy: Employed in the management of autoimmune conditions such as Crohn's disease and ulcerative colitis.
• Biochemical Research: Serves as a key reference standard and investigational compound in metabolic pathway and enzyme inhibition studies.
• Process Development: Utilized in the R&D and scale-up of synthetic routes for purine-based therapeutics.

Basic Information

Product Name	6-Mercaptopurine Monohydrate
CAS No.	6112-76-1
Molecular Formula	C5H4N4S·H2O
Molecular Weight	170.19 g/mol (Monohydrate)
Synonyms	6-MP Monohydrate; Mercaptopurine Monohydrate; Purinethol; 6-Thiohypoxanthine Monohydrate; 1,7-Dihydro-6H-purine-6-thione Monohydrate; NSC-755; Leukerin; 6-Mercaptopurine Hydrate
EINECS	Contact for details

Quality Control

Our 6-Mercaptopurine Monohydrate is manufactured under strict quality management systems, targeting compliance with pharmaceutical-grade standards. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis to ensure identity, purity, and strength. Certificates of Analysis (COA) documenting full compliance with agreed specifications are provided and traceable to each production lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow, crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	9.0% - 11.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.