Description

16 α-Isothiocyanopregnenolone-3-Acetate is a high-purity, synthetic steroid derivative characterized by its unique isothiocyanate functional group. This compound serves as a critical advanced pharmaceutical intermediate for the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in steroid chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel steroid-based drugs and bioactive molecules.
• Research Chemical: Used in academic and industrial research for studying steroid receptor interactions and metabolic pathways.
• Bioconjugation Probe: The reactive isothiocyanate group allows for covalent attachment to proteins or other biomolecules for labeling and targeting studies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Precursor for Modified Steroids: Used to create libraries of steroid analogs for screening in drug discovery campaigns.

Basic Information

Product Name	16 α-Isothiocyanopregnenolone-3-Acetate
CAS No.	6084-04-4
Molecular Formula	C23H31NO3S
Molecular Weight	401.57 g/mol
Synonyms	16α-Isothiocyanatopregnenolone Acetate; Pregnenolone-16α-isothiocyanate 3-acetate; 3β-Acetoxy-16α-isothiocyanatopregn-5-en-20-one; 16α-Isothiocyanato-3β-hydroxypregn-5-en-20-one 3-acetate; NSC 113986; 16-Isothiocyanatopregnenolone acetate; 16α-Isothiocyanato-5-pregnen-3β-ol-20-one acetate
EINECS	Contact for details

Quality Control

Our 16 α-Isothiocyanopregnenolone-3-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.