Description

Threo-α-Methylisocitrate CAS NO 6061-95-6 is a high-purity, stereochemically defined derivative of isocitric acid, serving as a critical biochemical intermediate and research standard. Its primary value lies in its role as a specific inhibitor of the enzyme aconitase, making it an indispensable tool for metabolic pathway studies, particularly within the Krebs (TCA) cycle. This compound is essential for researchers and manufacturers in the life sciences, pharmaceutical development, and fine chemical synthesis sectors who require precise biochemical probes or chiral building blocks.

Application

• Biochemical Research: Used as a specific and potent inhibitor of aconitase for studying mitochondrial metabolism, the TCA cycle, and cellular energy production.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of metabolic disorder therapeutics and enzyme-targeted drugs.
• Enzymology Studies: Employed to investigate enzyme kinetics, mechanism of action, and substrate specificity of aconitase and related iron-sulfur cluster enzymes.
• Metabolomics & Diagnostics: Acts as a calibration standard in mass spectrometry and chromatography for accurate quantification of cellular metabolites.
• Fine Chemical Synthesis: Utilized as a chiral synthon or building block for the asymmetric synthesis of complex organic molecules and natural product analogs.
• Nutritional Science Research: Applied in studies exploring cellular respiration, energy metabolism, and the biochemical effects of nutritional compounds.

Basic Information

Product Name	Threo-α-Methylisocitrate
CAS No.	6061-95-6
Molecular Formula	C7H10O7
Molecular Weight	206.15 g/mol
Synonyms	(1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid 2-methyl ester; (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylic acid 2-methyl ester; three-α-Methylisocitrate; threo-α-Methylisocitric acid; Methylisocitric acid; Aconitase inhibitor; 2-Methylisocitrate; (1R,2S)-2-Methylisocitrate
EINECS	Contact for details

Quality Control

Our Threo-α-Methylisocitrate is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is subjected to comprehensive analytical testing, including chiral purity verification, to confirm identity and potency. Certificates of Analysis (COA) detailing specific test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (threo isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.