Description

D-Threo-Dihydrosphingosine is a high-purity, synthetic sphingolipid backbone, a critical intermediate in the biosynthesis of complex sphingolipids and ceramides. This compound matters for its role as a key chiral building block in life science research and pharmaceutical development, enabling the study of cellular signaling, apoptosis, and lipid metabolism. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced cosmetics industries who require a reliable, high-quality standard for synthesizing bioactive lipids or developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel sphingolipid-based drugs, immunosuppressants, and enzyme inhibitors.
• Biochemical Research: Used as a standard and substrate in studies of sphingolipid metabolism, cell signaling pathways, and apoptosis mechanisms.
• Cosmetic Actives Development: Serves as a building block for synthesizing ceramides and other skin-barrier enhancing ingredients in advanced skincare formulations.
• Cell Culture & Media Supplements: Employed in specialized cell culture applications to investigate lipid-mediated cellular processes and membrane biology.
• Enzymology Studies: Acts as a substrate for enzymes like ceramide synthases and sphingosine kinases in kinetic and inhibitory assays.
• Reference Standard: Provides a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	D-Threo-Dihydrosphingosine
CAS No.	6036-86-8
Molecular Formula	C18H39NO2
Molecular Weight	301.51 g/mol
Synonyms	(2S,3R)-2-Amino-1,3-octadecanediol; D-erythro-Dihydrosphingosine; D-erythro-Sphinganine; (2S,3R)-2-Aminooctadecane-1,3-diol; Safingol; Sphinganine; Dihydro-D-erythro-sphingosine; 6036-86-8
EINECS	Contact for details

Quality Control

Our D-Threo-Dihydrosphingosine is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation by IR and MS. Certificates of Analysis (COA) with full traceability are provided, ensuring compliance with research and development standards. We support cGMP practices for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and minimize degradation. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to avoid moisture condensation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (D-erythro isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.