Description

7-Angeloylretronecine is a pyrrolizidine alkaloid (PA) derivative, a class of compounds with significant biological activity. This specific ester of retronecine is valued for its role as a key intermediate and reference standard in advanced chemical synthesis and toxicological research. It is primarily utilized by research institutions and pharmaceutical development companies focusing on natural product chemistry, metabolic studies, and safety assessments.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for the identification and quantification of pyrrolizidine alkaloids in herbal materials, supplements, and food products.
• Metabolic Pathway Research: Serves as a crucial intermediate in studies investigating the biosynthesis, metabolism, and detoxification pathways of hepatotoxic pyrrolizidine alkaloids.
• Toxicological Studies: Employed in in-vitro and in-vivo research to understand structure-activity relationships and the mechanisms of PA-induced toxicity.
• Natural Product Chemistry: Acts as a building block or comparative marker in the synthesis and analysis of complex natural products containing the retronecine nucleus.
• Quality Control Laboratories: Essential for developing and validating analytical methods (e.g., HPLC, LC-MS) to ensure the safety and compliance of consumer products concerning PA contamination.

Basic Information

Product Name	7-Angeloylretronecine
CAS No.	6029-82-9
Molecular Formula	C13H19NO4
Molecular Weight	253.30 g/mol
Synonyms	Retronecine 7-angelate; 7α-Angeloyloxy-1β,2β-epoxy-8β-hydroxymethylpyrrolizidine; (-)-7-Angeloylretronecine; (1R,7aR)-1-(Hydroxymethyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl (2Z)-2-methylbut-2-enoate
EINECS	Contact for details

Quality Control

Our 7-Angeloylretronecine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by advanced chromatographic methods. We adhere to relevant industry standards for reference materials to support your compliance and research integrity needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.