Description

D-Tetrahydropalmatine is a purified isoquinoline alkaloid derived from botanical sources, known for its specific stereochemistry. This compound is valued in research and development for its role as a key reference standard and active pharmaceutical ingredient (API) intermediate. It is primarily sought by manufacturers and researchers in the pharmaceutical, nutraceutical, and life science sectors for developing therapeutic formulations and conducting pharmacological studies.

Application

• Pharmaceutical Research: Serves as a critical reference standard and intermediate in the development of central nervous system (CNS) targeting drugs.
• Active Pharmaceutical Ingredient (API): Used in the synthesis and formulation of finished dosage forms for clinical applications.
• Nutraceutical Formulations: Incorporated into dietary supplements targeting specific wellness pathways, subject to regional regulatory compliance.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate receptor binding activity and pharmacological mechanisms.
• Analytical Chemistry: Used as a high-purity calibrant in HPLC, LC-MS, and other chromatographic methods for quality control laboratories.
• Preclinical Development: Essential for pharmacokinetic, pharmacodynamic, and toxicology studies during drug discovery phases.

Basic Information

Product Name	D-Tetrahydropalmatine
CAS No.	6024-83-5
Molecular Formula	C21H25NO4
Molecular Weight	355.43 g/mol
Synonyms	(-)-Tetrahydropalmatine; L-Tetrahydropalmatine; (13aS)-2,3,9,10-Tetramethoxy-13a-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[2,1-b]isoquinoline; NSC 169016; THP; Rotundine; Corydalis B; Gindarine
EINECS	Contact for details

Quality Control

Our D-Tetrahydropalmatine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via HPLC, to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation	-290° to -300° (c=1 in CHCl3)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.