Description

R(-)-Apocodeine Hydrochloride is a specific enantiomer of the semi-synthetic opiate alkaloid derivative, apocodeine. This high-purity chiral compound is of significant value in advanced pharmaceutical research and development, particularly for studying stereospecific biological activity. It serves as a critical reference standard and a key synthetic intermediate for specialized medicinal chemistry applications. Researchers and developers in the pharmaceutical and fine chemical sectors utilize this material for its defined stereochemistry and consistent quality.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control testing in drug discovery and manufacturing.
• Medicinal Chemistry Research: Serves as a chiral building block or precursor in the synthesis of novel therapeutic agents targeting neurological pathways.
• Pharmacological Studies: Employed in in-vitro and in-vivo studies to investigate the stereospecific binding, metabolism, and physiological effects of opiate-related compounds.
• Analytical Testing: Acts as a high-purity calibrant in chromatographic (HPLC, GC) and spectroscopic analyses for accurate compound identification and quantification.
• Academic & Institutional Research: Utilized in university and institutional labs for chemical education and advanced research into alkaloid chemistry and pharmacology.

Basic Information

Product Name	R(-)-Apocodeine Hydrochloride
CAS No.	641-36-1
Molecular Formula	C₁₈H₂₁NO₃ • HCl
Molecular Weight	335.82 g/mol
Synonyms	(-)-Apocodeine Hydrochloride; (R)-Apocodeine HCl; 1,2,3,4-Tetradehydro-7,8-dimethoxy-17-methyl-6α-apomorphine Hydrochloride; 6aβ-Apocodeine Hydrochloride; R-(-)-Apocodeine Hydrochloride; Apocodeine Hydrochloride (R-isomer); NSC 134454
EINECS	Contact for details

Quality Control

Our R(-)-Apocodeine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, identity confirmation by IR and NMR spectroscopy, and stringent control of impurities. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.