Description

Desonide CAS NO 638-94-8 is a synthetic, low-potency corticosteroid with potent anti-inflammatory and antipruritic properties. This compound is a critical active pharmaceutical ingredient (API) valued for its efficacy in managing inflammatory skin conditions with a favorable safety profile. It is primarily required by pharmaceutical manufacturers and research institutions developing topical dermatological formulations such as creams, ointments, and lotions for the treatment of eczema, psoriasis, and other dermatoses.

Application

• Primary Active Pharmaceutical Ingredient (API) in topical corticosteroid creams and ointments.
• Formulation of dermatological products for the treatment of atopic dermatitis and eczema.
• Key component in prescription medications for managing pruritus and inflammation associated with psoriasis.
• Use in compounding pharmacies for customized dermatological preparations.
• Research and development of new topical anti-inflammatory drug delivery systems.
• Reference standard in analytical laboratories for quality control and method development.

Basic Information

Product Name	Desonide
CAS No.	638-94-8
Molecular Formula	C24H32O6
Molecular Weight	416.51 g/mol
Synonyms	Desonide; 11β,21-Dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-; Tridesilon; Sterolon; Apolar; 16α,17-Isopropylidenedioxyprednisolone
EINECS	211-354-1

Quality Control

Our Desonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.