Description

Homatropine Hydrochloride CAS NO 637-21-8 is a quaternary ammonium anticholinergic agent, a salt form of homatropine that enhances its stability and solubility for pharmaceutical formulation. This compound is valued for its potent mydriatic and cycloplegic properties, enabling precise ophthalmic examinations and treatments. It is primarily required by manufacturers in the pharmaceutical and ophthalmic sectors for producing diagnostic and therapeutic agents.

Application

• Ophthalmic Solutions: As an active pharmaceutical ingredient (API) in eye drops and solutions for inducing mydriasis (pupil dilation) and cycloplegia (paralysis of accommodation) during eye examinations and surgeries.
• Diagnostic Agents: Used in the formulation of diagnostic kits and solutions for refractive error assessment and fundoscopic examination.
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate or precursor in the production of other specialized anticholinergic drugs.
• Research & Development: Utilized in biochemical and pharmacological research to study muscarinic acetylcholine receptor antagonism and related physiological pathways.
• Veterinary Medicine: Applied in veterinary ophthalmic preparations for diagnostic procedures in animals.
• Controlled Drug Delivery Systems: Incorporated into advanced drug delivery matrices for sustained-release ophthalmic applications.

Basic Information

Product Name	Homatropine Hydrochloride
CAS No.	637-21-8
Molecular Formula	C16H22ClNO3
Molecular Weight	311.80 g/mol
Synonyms	Homatropine HCl; Tropyl Mandelate Hydrochloride; (1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 2-hydroxy-2-phenylacetate hydrochloride; DL-Homatropine Hydrochloride; Mandelyltropine Hydrochloride; Tropine Mandelate Hydrochloride; Benzeneacetic acid, α-hydroxy-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrochloride
EINECS	211-291-9

Quality Control

Our Homatropine Hydrochloride is manufactured and tested under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical applications, with testing protocols aligned with pharmacopeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (Chloride)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	-0.10° to +0.10°
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.