Description

Oxythiamine Hydrochloride is a synthetic thiamine (vitamin B1) analog that acts as a potent and specific antagonist of thiamine-dependent enzymes. This compound is a critical research tool for studying thiamine metabolism and its role in cellular processes. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biochemical, and nutritional science sectors for metabolic studies and as a reference standard.

Application

• Biochemical Research: Used as a specific inhibitor to study thiamine-dependent enzymes like transketolase and pyruvate dehydrogenase in metabolic pathways.
• Pharmaceutical R&D: Serves as a reference standard and a key intermediate in the development of novel therapeutic agents targeting metabolic disorders.
• Nutritional Science Studies: Employed to induce experimental thiamine deficiency models to understand the vitamin's physiological roles and the effects of its antagonism.
• Enzyme Kinetics: A vital tool for investigating enzyme mechanisms, inhibition constants (Ki), and the structural requirements for thiamine cofactor binding.
• Academic Research: Used in university and institutional labs for fundamental research in biochemistry, cell biology, and molecular nutrition.
• Quality Control: Can be utilized as an analytical standard in HPLC or other methods for the quality assessment of thiamine and related compounds.

Basic Information

Product Name	Oxythiamine Hydrochloride
CAS No.	614-05-1
Molecular Formula	C12H16ClN4OS
Molecular Weight	300.80 g/mol
Synonyms	Oxythiamine HCl; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride; Thiamine Antagonist; Vitamin B1 Antagonist; 2-Methyl-4-amino-5-pyrimidinylmethyl thiazolium derivative; Neopyrithiamine (related analog); Pyrithiamine (related analog)
EINECS	210-356-9

Quality Control

Our Oxythiamine Hydrochloride is produced under a rigorous quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.